The diagnosis of hydrocephalus and shunt malfunction can be difficult and often requires more information than can be provided by MRI, CT, or ultrasound. Our St Louis investigator, Dr David Limbrick has begun the search for biomarkers of hydrocephalus and shunt malfunction. He is testing CSF and blood from infants suffering from post-hemorrhagic hydrocephalus in order to identify proteins that can be used for early diagnosis. In addition these proteins may provide real-time feedback on the effectiveness of treatment. Ultimately, we hope that these or similar biomarkers will provide a tool to complement current imaging methods and facilitate the diagnosis and treatment of hydrocephalus.

I am excited to announce that Jay Riva-Cambrin received one of two Mentored Young Investigator Awards from the Hydrocephalus Association this year. Jay’s project will investigate whether ventricle size is associated with neuropsychological outcomes. It will focus on school aged children (5-17 years) with a new diagnosis of hydrocephalus. They will have neuropsychology testing before their hydrocephalus is treated and six months afterward. In addition, the study will evaluate the neuropsychology tests. At present, there are a large number of tests that are complex and not easily used in clinical practice because they are expensive, time consuming and not specific to hydrocephalus. Dr. Riva-Cambrin’s study will determine whether these tests can be narrowed down, and identify the few most meaningful ones that can be used more efficiently with less expense and provide more specific information about hydrocephalus.

Prior to receiving the funding, Jay presented the study idea to the HCRN investigators. Regardless of funding, it was selected as a new HCRN project.

Congratulations Jay on getting this going and on receiving the HA Mentored Young Investigator Award!